Mechanism of Action
RADIESSE® wrinkle filler is an injectable implant composed of synthetically produced smooth calcium hydroxylapatite (CaHA) microspheres (diameter of 25µm to 45µm) suspended in a sodium carboxymethylcellulose gel carrier. RADIESSE wrinkle filler is approximately 30% CaHA and 70% gel carrier by volume.
RADIESSE wrinkle filler is injected into the skin in a minimally invasive procedure. Injection of the product provides an immediate one-to-one correction of the face wrinkle. The amount of filling or augmentation can be easily placed and controlled for better results. There is no skin sensitivity testing or reconstitution required.
Over time, the gel is absorbed, and fibroblasts appear. The process of neocollagenesis begins, stimulating the gradual growth of the patient's own collagen. The collagen that forms results in extended correction times and increased patient satisfaction.
The cosmetic results are soft and natural-looking, and feel like the patient's own tissue. The results are long-lasting, but not permanent. The CaHA microspheres naturally degrade to calcium and phosphate ions, which are metabolized by the body's normal processes.
How It Works
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Upon injection, RADIESSE wrinkle filler immediately adds volume to facial features. |
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After two to three months, macrophages start to dissolve the sodium carboxymethylcellulose gel carrier. The CaHA microspheres remain. |
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Macrophages continue to dissolve the gel carrier. Fibroblasts form new collagen. |
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New resident tissue (collagen) surrounds the CaHA microspheres. |
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The CaHA microspheres degrade and are phagocytized and metabolized by macrophages. |
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Even the small fragments of CaHA are decomposed at the implant site, without evidence of migration. |
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